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B Positive is very much designed to function in a mode similar to Mom, where some episodes can be schtick-y and full of easy punchlines, but the show is still able to shift gears into emotional, borderline dramatic episodes.
It's about time that someone gave Tony-winning spitfire Annaleigh Ashford a lead role that takes full advantage of her madcap personality and offbeat comic timing... Ashford is warm, wacky, larger and weirder than life.
It has an admittedly odd premise and does fall into certain CBS sitcom pitfalls along the way, but it's redeemed by stars Thomas Middleditch and Annaleigh Ashford, who make a stellar comedic duo right away.