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In 2056, a disease caused by the body organs of people crippled spreads around the planet. From tragedy, a savior appeared: GeneCo, a biotech company providing organs transplanted tissue for profit. Those who fail in paying on time is to regain authority is chased by thugs Repo Men. In a world of surgery, painkillers and murder is legally permited, a little girl goes to seek to cure her rare disease as well as information about her mysterious family. After being swept into the world of GeneCo, she can not go back, and all of her questions will be answered to a spectacular event is predicted to be mad: The Genetic Opera.